Manual Prepositioning Antibiotics for Anthrax

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Each report has been subjected to a rigorous and independent peer-review process and it represents the position of the National Academies on the statement of task. If terrorists released Bacillus anthracis over a large city, hundreds of thousands of people could be at risk of the deadly disease anthrax-caused by the B.

Multiple Strategies Needed

Although plans for rapidly delivering MCM to a large number of people following an anthrax attack have been greatly enhanced during the last decade, many public health authorities and policy experts fear that the nation's current systems and plans are insufficient to respond to the most challenging scenarios, such as a very large-scale anthrax attack.

The U. Department of Health and Human Services' Office of the Assistant Secretary for Preparedness and Response commissioned the Institute of Medicine to examine the potential uses, benefits, and disadvantages of strategies for repositioning antibiotics.

This involves storing antibiotics close to or in the possession of the people who would need rapid access to them should an attack occur.

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Prepositioning Antibiotics for Anthrax reviews the scientific evidence on the time window in which antibiotics successfully prevent anthrax and the implications for decision making about prepositioning, describes potential prepositioning strategies, and develops a framework to assist state, local, and tribal public health authorities in determining whether prepositioning strategies would be beneficial for their communities.

However, based on an analysis of the likely health benefits, health risks, and relative costs of the different prepositioning strategies, the book also develops findings and recommendations to provide jurisdictions with some practical insights as to the circumstances in which different prepositioning strategies may be beneficial.


Finally, the book identifies federal- and national-level actions that would facilitate the evaluation and development of prepositioning strategies. Recognizing that communities across the nation have differing needs and capabilities, the findings presented in this report are intended to assist public health officials in considering the benefits, costs, and trade-offs involved in developing alternative prepositioning strategies appropriate to their particular communities. The National Academies Press and the Transportation Research Board have partnered with Copyright Clearance Center to offer a variety of options for reusing our content.

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Loading stats for Prepositioning Antibiotics for Anthrax This involves storing antibiotics close to or in the possession of the people who would need rapid access to them should an attack occur. The IOM defined and evaluated three categories of prepositioning strategies that could complement existing, centralized stockpiling strategies, including the Strategic National Stockpile maintained by the Centers for Disease Control and Prevention. Prepositioning Antibiotics for Anthrax.

IOM: States, locals should decide where to store anthrax drugs | CIDRAP

The group's four meetings included two open sessions and a 2-day public workshop. The panel considered the benefits and costs of each strategy, as well how locations have different risks of attack and dispensing capabilities. According to the report, some of the group's concerns and deliberations were influenced by challenges encountered during the distribution of the H1N1 pandemic influenza vaccine.

State, local, and tribal health officials should work with federal authorities to assess the different options and decide on the best and speediest strategy, the group recommended.

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However, they advised against broad use of home storage, citing possible antibiotic misuse and higher costs of administering such systems. The committee found limited evidence that developing a MedKit approved by the US Food and Drug Administration FDA would lower the risk of inappropriate use, but suggested that targeted personal stockpiling might be helpful for some groups, such as for first responders, healthcare workers, people who play other critical roles, and those who can't travel to antibiotic dispensing sites because of medical conditions.

The report contains detailed guidance to help policymakers and public health officials assess the benefits of different prepositioning strategies, such as factors to consider in gauging the risk of an attack and the ability to quickly detect one. Among other findings, the group noted that prepositioning a single type or class of antibiotic would reduce the flexibility to respond to a resistant B anthracis strain.

In examining the limited scientific data on inhalational anthrax incubation times, they said the most probable minimum period is about 4 days, and that the current goal of completing prophylaxis distribution is appropriate, so long as the interval from exposure to prophylaxis is no longer than 96 hours.

Additional recommendations include developing national guidance for public-private coordination on prepositioning activities, distribution, and dispensing. The experts also urged HHS to conduct more research to address uncertainty over prepositioning issues, particularly in the areas of epidemiology, clinical issues, logistics, behavior and demographics, safety, and cost-effectiveness. Sep 30 IOM report.

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